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Ciraulo DA, Shader RI. Fluoxetine drug-drug interactions: I. Antidepressants and antipsychotics. If a large amount of tyramine is absorbed systemically, it is taken up by adrenergic neurons and causes norepinephrine release from neuronal storage sites with resultant elevation of blood pressure. While most foods contain negligible amounts or no tyramine, a few food products see may contain large amounts of tyramine that represent a potential risk for patients with significant inhibition of intestinal MAO-A resulting from administration of MAOIs. Tyramine-containing nutritional supplements should be avoided by patients taking EMSAM selegiline transdermal system. vilus.info rhinocort

Skin and Appendages: Pruritus

Elavil as well as months of weekly outpatient ECT treatments all failed to provide me with the degree of relief from depression that I got with Emsam 12 mg. The 6 mg and 9 mg patches were helpful, but 12 mg is best for me. I've been on the 12 mg patch for over 3 years. Biggest downside: inconvenience of patch. All pediatric patients being treated with antidepressants for any indication should be observed closely for clinical worsening, suicidality, and unusual changes in behavior, especially during the initial few months of a course of drug therapy, or at times of dose changes, either increases or decreases. Such observation would generally include at least weekly face-to-face contact with patients or their family members or caregivers during the first 4 weeks of treatment, then every other week visits for the next 4 weeks, then at 12 weeks, and as clinically indicated beyond 12 weeks. Additional contact by telephone may be appropriate between face-to-face visits.

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Have a family or personal history of successful treatment with MAOIs. Both of these medicines can increase the level of serotonin in your body. Gently wash the old application site with warm water and a mild soap to remove any sticky material adhesive that stays on your skin after removing the patch. A small amount of baby oil may also be used to remove any adhesive. You may need to use a medical adhesive removal pad that you can get from your pharmacist. Alcohol or other dissolving liquids such as nail polish remover may cause skin irritation and should not be used. Fluvoxamine Maleate Tablets unless directed to do so by your physician.

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What should I avoid while taking methylphenidate? Kahn DA. Possible toxic interaction between cyproheptadine and phenelzine. General information about the safe and effective use of Emsam. Here's where to learn why doctors sometimes prescribe certain of these for bipolar mania.

Side effects of emsam

What should I discuss with my healthcare provider before using epinephrine injection? Although the effects of heat on the patch are not known, the drug labeling advises doctors and patients about the possible effects of direct heat applied to the Emsam patch. Tablets are not approved for use in treating bipolar depression. One study using a crossover design in 13 subjects investigated tyramine pressor doses TYR30 after administration of EMSAM 6 mg per 24 hours and oral selegiline 5 mg twice daily for 9 days. Mean pressor doses TYR30 of tyramine capsules administered without food were 338 mg and 385 mg in subjects treated with EMSAM and oral selegiline, respectively. MAOI antidepressant. When applied to intact skin, Emsam is designed to continuously deliver selegiline over a 24-hour period. Selegiline prevents the breakdown of chemicals in the brain that are often imbalanced in people with depression. This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Apply the transdermal system to an area of skin that is not hairy, oily, irritated, broken, scarred or calloused. Do not place the transdermal system where your clothing is tight, which could cause the transdermal system to rub off. R--methamphetamine and R--amphetamine are mainly excreted unchanged in urine.

Selegiline isn't a new drug

An increase in post-implantation loss was seen at the mid and high doses, and an increase in stillborn pups was seen at the high dose. Decreases in pup weight throughout lactation and postweaning periods and survival throughout lactation period delayed pup physical development, and pup epididymal and testicular hypoplasia, were seen at the mid and high doses. Delayed neurobehavioral and sexual development was seen at all doses. Adverse effects on pup reproductive performance, as evidenced by decreases in implantations and litter size, were seen at the high dose. These findings suggest persistent effects on the offspring of treated dams. A no-effect dose was not established in this study for developmental toxicity. In this study, concentrations of selegiline and its metabolites in milk were approximately 15 and 5 times, respectively, the concentrations in maternal plasma, indicating that the pups were directly dosed during the lactation period. Maleate Tablets before you start taking it and each time you get a refill. Both medicines increase the amount of certain naturally occurring messengers norepinephrine and dopamine in the brain. EMSAM 6 mg per 24 hours for 7 days of treatment was examined in 16 healthy volunteers. No clinically significant differences were observed in the pharmacokinetics or pharmacodynamics of alcohol or the pharmacokinetics of selegiline during co-administration. FDA pregnancy category C. It is not known whether selegiline will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Emsam is not for children less than 12 years of age. Emsam may cause a severe increase in blood pressure in children less than 12 years of age. Table 2. Treatment-Emergent Adverse Reactions: Incidence in Placebo-Controlled Clinical Trials for Major Depressive Disorder with Emsam Reactions reported by at least 2% of patients treated with Emsam are included, except the following reactions, which had an incidence on placebo treatment greater than or equal to Emsam: infection, nausea, dizziness, pain, abdominal pain, nervousness, back pain, asthenia, anxiety, flu syndrome, accidental injury, somnolence, rhinitis, and palpitations. Seleegiline FDA Approved Prescribing Information including Dosage. Warning: The facts and figures contained in these reports are accurate to the best of our capability; however, our metrics are only meant to augment your medical knowledge, and should never be used as the sole basis for selecting a new medication. As with any medical decision, be sure to work with your doctor to ensure the best choices are made for your condition. Keep out of the reach of children. After you have selected the site for your transdermal system, wash the area gently and thoroughly with soap and warm water. Rinse until all soap is removed. Dry the area with a clean dry towel. Musculoskeletal System: Frequent: Myalgia, pathological fracture. Infrequent: Arthralgia, generalized spasm, arthritis, myasthenia, arthrosis, tenosynovitis. Rare: Osteoporosis. biaxin

Emsam uses

Boyson SJ "Psychiatric effects of selegiline. It has an empirical formula of C 13H 17N and a molecular weight of 187. Emsam. Emsam had no clinically relevant effect on pharmacokinetics of these drugs. It is not known whether methylphenidate passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Changes in plasma selegiline concentrations were nearly 2-fold and variable across the subject population. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Emsam system while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use Emsam system, check with your doctor. Discuss any possible risks to your baby. Dose increases, in the elderly, should be made with caution and patients should be closely observed for postural changes in blood pressure throughout treatment. Read the “Instructions for Use” at the end of this Medication Guide for information about the right way to use EMSAM. Screening Patients for Bipolar Disorder: A major depressive episode may be the initial presentation of bipolar disorder. Diskets Dispersible methadone hydrochloride US prescribing information. Diagnosis of major depressive disorder single episode or recurrent, moderate to severe was based on according DSM-IV criteria and Kiddie Schedule for Affective Disorders and Schizophrenia for School Aged Children K-SADS. In vivo Metabolism: Transdermally absorbed selegiline via EMSAM is not metabolized in human skin and does not undergo extensive first-pass metabolism. Selegiline is extensively metabolized by several CYP450-dependent enzyme systems see In vitro Metabolism. Selegiline is metabolized initially via N-dealkylation or N-depropargylation to form N-desmethylselegiline or R--methamphetamine, respectively. Both of these metabolites can be further metabolized to R--amphetamine. After you have applied the patch, wash your hands thoroughly with soap and water to remove any medicine that may have gotten on them. Do not touch your eyes until after you have washed your hands.

Before taking emsam

The cause of the interaction is unknown. Fluvoxamine Maleate Tablets with your other medicines. Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first. Application Site Reactions: In the pool of short-term, placebo-controlled major depressive disorder studies, application site reactions ASRs were reported in 24% of EMSAM-treated patients and 12% of placebo-treated patients. Most ASRs were mild or moderate in severity. ASRs led to dropout in 2% of EMSAM-treated patients and no placebo-treated patients. If you forget to change your patch after 24 hours, remove the old patch. Put on a new patch in a different area and continue to follow your normal schedule for changing patches. If you have any of these symptoms of Emsam overdosage, remove your patch right away and call your healthcare provider or go to the nearest hospital emergency room right away. It may take up to 12 hours before you have these symptoms, and they may be worse 24 to 48 hours after you apply your Emsam patch. Excretion: Approximately 10% and 2% of a radiolabeled dose applied dermally, as a DMSO solution, was recovered in urine and feces respectively, with at least 63% of the dose remaining unabsorbed. The remaining 25% of the dose was unaccounted for. Indications and Usage 1 and Clinical Studies 14. cheap atenolol in australia

Prescribing information for emsam

Brewer's or baker's yeast. Lotronex TM alosetron package insert. Kline SS, Mauro LS, Scala-Barnett DM, Zick D. Serotonin syndrome versus neuroleptic malignant syndrome as a cause of death. There are no adequate and well-controlled studies in pregnant women. EMSAM should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is important to talk with your healthcare provider about the risks of treating depression and also the risk of not treating it. You should discuss all treatment choices with your healthcare provider. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. In the pool of short-term, placebo-controlled major depressive disorder studies, application site reactions ASRs were reported in 24% of Emsam-treated patients and 12% of placebo-treated patients. Most ASRs were mild or moderate in severity. ASRs led to dropout in 2% of Emsam-treated patients and no placebo-treated patients. Throw away the folded patch so that children and pets cannot reach it. This patch still contains some medicine and could harm a child or pet. Lab tests, including blood pressure and skin checks, may be performed while you use Emsam system. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Pooled analyses of short-term 4 to 16 weeks placebo-controlled trials of nine antidepressant drugs SSRIs and others in children and adolescents with major depressive disorder MDD obsessive compulsive disorder OCD or other psychiatric disorders a total of 24 trials involving over 4400 patients have revealed a greater risk of adverse events representing suicidal thinking or behavior suicidality during the first few months of treatment in those receiving antidepressants. The average risk of such events in patients receiving antidepressants was 4%, twice the placebo risk of 2%. No suicides occurred in these trials.

How to take emsam

Ask your health care provider any questions you may have about how to use Emsam system. Your healthcare professionals may be aware of this interaction and may be monitoring you for it. Do not start, stop, or change your medicine or diet before checking with them first. This may make you sleepy during the day. Tell your doctor if you have daytime drowsiness. Your dose may need to be adjusted. OCD have not been established. Your doctor may occasionally change the timing of your dose to make sure you get the best results. Millaril many years ago and I don't remember what it did because I was taken off of it obviously because it wasn't working. Trazadone put weight on me and eventually quit working. I don't think I have been on Restoril. I will look it up. I really want off Seroquel. I am on disability and over the years it has turned into Treatment Resistant Depression. I don't have many drugs left to consider, so I looked into Vagal Nerve Stimulator. I am trying to get it set up but my psychiatrist said they most likely require Electric Shock Treatments, I hope not that scares me. I'm confused about what I should decide on. I know I want the VNS above. Medicare does cover some of it and I have AARP but the surgery costs. Emsam is not a controlled substance. pioglitazone cost with no insurance

Emsam warnings

Viibryd vilazodone hydrochloride US prescribing information. Forest Laboratories Inc. April, 2014. Preliminary research shows that ashwagandha in combination with an alternative form of medicine known as Ayurvedic therapy might improve balance in people with cerebellar ataxia. Appetite changes or gain. The use of EMSAM with sympathomimetic amines or buspirone may produce substantial elevations in blood pressure. Only one EMSAM patch should be worn at a time. Eating foods high in tyramine eg, aged cheeses, red wines, beer, certain meats and sausages, liver, sour cream, soy sauce, raisins, bananas, avocados while you use an MAOI may cause severe high blood pressure. Such a reaction is NOT likely to occur with this dose of Emsam system. People who use this dose can eat a normal diet. Although this is not likely to occur, seek medical attention at once if symptoms of severe high blood pressure occur. These may include severe headache, fast or irregular heartbeat, sore or stiff neck, nausea, vomiting, sweating, enlarged pupils, or sensitivity to light. Hold the patch with the protective liner facing you. Selegiline the drug substance of EMSAM is an irreversible inhibitor of monoamine oxidase MAO an intracellular enzyme associated with the outer membrane of mitochondria. MAO exists as two isoenzymes, referred to as MAO-A and MAO-B. Selegiline has a greater affinity for MAO-B, compared to MAO-A. However, at antidepressant doses, selegiline inhibits both isoenzymes see below. Azilect rasagiline US prescribing information. Teva Neurosciences Inc. Azilect rasagiline US prescribing information. Teva Neurosciences Inc. October, 2014. Emsam selegiline transdermal system contains a monoamine oxidase inhibitor MAOI. MAOIs including Emsam combined with a high tyramine diet may cause a hypertensive crisis. EMSAM selegiline transdermal system has not been shown to impair psychomotor performance; however, any psychoactive drug may potentially impair judgment, thinking, or motor skills. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that EMSAM therapy does not impair their ability to engage in such activities. Emsam helps my depression more than anything I've tried. The ease of use is excellent. I have fibromyalgia and this might also be helping my pain, fatigue, and libido since I've noticed improvement with all. At first I craved sweets but don't now. I have mild irritation at the patch site. I wake up at least once at night to urinate where I didn't before and I also want a snack at that time, too. Even with night eating, I think I'm losing weight on this medication. Concomitant use of EMSAM with buspirone hydrochloride is not advised since several cases of elevated blood pressure have been reported in patients taking MAOIs who were then given buspirone HCl. MAO exists as two isoenzymes, referred to as MAO-A and MAO-B. Selegiline has a greater affinity for MAO-B, compared to MAO-A. However, at antidepressant doses, selegiline inhibits both isoenzymes.

Emsam forms and strengths

Who should not take Fluvoxamine Maleate Tablets? The following adverse reactions have been identified during post-approval use of EMSAM. If levels of the natural messengers are too high you may have an increased risk for side effects such as a large increase in your blood pressure, anxiety, changes in your thoughts, mania, palpitations, agitation, tremors, or seizures. The main characteristic of atypical depression that distinguishes it from melancholic depression is mood reactivity. In other words, the person with atypical depression will see his or her mood improve if something positive happens. In melancholic depression, positive changes will seldom bring on a change in mood. Table 3 shows that the incidence rates of sexual side effects in patients with major depressive disorder are comparable to the placebo rates in placebo-controlled trials. Where can I get more information? When applied to intact skin, EMSAM is designed to continuously deliver selegiline over a 24-hour period. How should I use EMSAM? Kurlan R, Dimitsopulos T "Selegiline and manic behavior in Parkinson's disease. Until there is another alternative from a new medication, drug class, treatment or cure I will be on emsam unless it loses its efficacy almost completely. Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Store at room temperature away from moisture, heat, and light. Do not refrigerate this medication, and do not store it in a car. montelukast

Use of emsam

Ashwagandha is also used as an "adaptogen" to help the body cope with daily stress, and as a general tonic. The only common side effect of Emsam detected in -controlled trials was a mild skin reaction where the patch is placed. There may be mild redness at the site when a patch is removed. Read this Medication Guide carefully before you start using EMSAM and each time you get a refill. There may be new information. This information does not take the place of talking with your doctor about your medical condition or your treatment. If you have any questions about EMSAM, ask your doctor or pharmacist. How is atypical depression treated? High serotonin levels may cause changes in body temperature, blood pressure and behavior, leading to a medical condition called Serotonin Syndrome. Serotonin Syndrome may be life threatening. There are different types of psychotherapy and medications available for treatment. You may be referred to a specialist such as a psychiatrist, psychologist, or other licensed professional for care. The antidepressant action of EMSAM in hospitalized depressed patients has not been studied. If a hypertensive crisis occurs, EMSAM should be discontinued immediately and therapy to lower blood pressure should be instituted immediately. Phentolamine 5 mg or labetalol 20 mg administered slowly intravenously is recommended therapy to control hypertension. Alternately, nitroprusside delivered by continuous intravenous infusion may be used. Fever should be managed by means of external cooling. Patients must be closely monitored until symptoms have stabilized.

About emsam

How should I use Emsam? Fold the patches in half with the sticky sides together and throw the patches away in a container with a lid. Prescribers or other health professionals should inform patients, their families, and their caregivers about the benefits and risks associated with treatment with EMSAM and should counsel them in its appropriate use. A patient Medication Guide About Using Antidepressants in Children and Teenagers is available for EMSAM. The prescriber or health professional should instruct patients, their families, and their caregivers to read the Medication Guide and should assist them in understanding its contents. Patients should be given the opportunity to discuss the contents of the Medication Guide and to obtain answers to any questions they may have. The complete text of the Medication Guide is reprinted at the end of this document. Alcohol: Patients should be told that, although EMSAM has not been shown to increase the impairment of mental and motor skills caused by alcohol, the concomitant use of EMSAM and alcohol in depressed patients is not recommended. Emsam overdosage may resemble overdosage with other nonselective, oral MAOI antidepressants and present with any of the following: drowsiness, dizziness, faintness, irritability, hyperactivity, agitation, severe headache, hallucinations, trismus, opisthotonos, convulsions, coma, rapid and irregular pulse, hypertension, hypotension and vascular collapse, precordial pain, respiratory depression and failure, hyperpyrexia, diaphoresis, and cool, clammy skin. Do not keep outdated medicine or medicine no longer needed. Do not store outside of the sealed pouch. What are the possible side effects of Emsam? Methylphenidate may also be used for purposes not listed in this medication guide. MAOIs may not be the first medicines given for anxiety, because the side effects can be severe. But MAOIs are the treatment of choice in cases of anxiety or with unusual features, such as a heavy feeling in the arms and legs, sensitivity to rejection, and a reactive mood. MAOIs are often used as an alternative treatment for anxiety or that has not responded to other medicines. Emsam system is a monoamine oxidase inhibitor MAOI. Exactly how Emsam system works to treat depression is unknown. You should call your child's healthcare provider between visits if needed. The potential for selegiline or N-desmethylselegiline to inhibit individual CYP 450-dependent enzyme pathways was also examined in vitro with human liver microsomes. epivir buy now online shop

Emsam adult dosage

Combined drug therapy in depressive illness. Gillman PK. Methylene blue implicated in potentially fatal serotonin toxicity. Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. Tell your doctor or dentist that you take Emsam system before you receive any medical or dental care, emergency care, or surgery. EMSAM is a matrix-type transdermal system composed of three layers as illustrated in Figure 1 below. Treatment should include supportive measures, with pharmacological intervention as appropriate. Symptoms may persist after drug washout because of the irreversible inhibitory effects of these agents on systemic MAO activity. With overdosage, in order to avoid the occurrence of hypertensive crisis "cheese reaction" dietary tyramine should be restricted for several weeks beyond recovery to permit regeneration of the peripheral MAO-A isoenzyme. Limited pharmacokinetic data with doses lower than in the commercially available formulations suggest that children under age 12 may be exposed to increased levels of selegiline compared to adolescents and adults, administered with and without dietary modifications, therefore, there may be an increased risk of hypertensive crisis, even at the lowest dose of EMSAM. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Emsam consumer information

Other side effects can occur with antidepressants see section below. The once-a-day patch, called Emsam, works by delivering selegiline, a monoamine oxidase inhibitor or MAOI, through the skin and into the bloodstream. Some MEDICINES MAY INTERACT with Emsam system. EMSAM is an irreversible MAO inhibitor. As a class, these compounds have been associated with hypertensive crises caused by the ingestion of foods containing high amounts of tyramine. What is Fluvoxamine Maleate Tablets? The following adverse reactions are discussed in greater detail in other sections of the label. EMSAM can cause serious and potentially life-threatening reactions if used with certain other medicines. Along with its benefits, this medication may rarely cause abnormal drug-seeking behavior . This risk may be increased if you have abused alcohol or drugs in the past. Take this medication exactly as prescribed to lessen the risk of addiction. If the patch becomes loose, press it back in place. If your Emsam patch falls off, apply a new Emsam patch to a new site and follow your normal schedule for changing patches. Any spoiled or improperly stored meat, poultry, and fish. These are foods that have a change in color, odor, or become moldy. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Like other MAOIs, selegiline has carried warnings about possible dangerous interactions with certain foods and drinks, including aged cheeses and tap beer. The new patch's lowest dose may avoid some of those interactions. Actions” is available for Fluvoxamine Maleate Tablets. Do not use this medicine if you also take selegiline capsules or tablets. You may see mild redness at the site when a patch is removed. This redness should go away within several hours after removing the patch. If irritation or itching continues, tell your healthcare provider. buy clozapine online au

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General information about emsam

Emsam dosing information

Methylphenidate may be habit-forming and should be used only by the person it was prescribed for. Never share methylphenidate with another person, especially someone with a history of drug abuse or addiction. Consistent with competitive inhibition, both selegiline and N-desmethylselegiline caused a concentration dependent inhibition of CYP2D6 at 10 to 250 mcM and CYP3A4 and CYP3A5 at 25 to 250 mcM. CYP2C19 and CYP2B6 were also inhibited at concentrations of 100 mcM or greater. Serious. These medicines may interact and cause very harmful effects.

Highlights for emsam

Let your doctor know if you experience any restlessness, confusion, or become disorientated. Reliable estimates of the incidence and severity of untoward experiences involving sexual desire, performance, and satisfaction are difficult to obtain, in part because patients and physicians may be reluctant to discuss them. Accordingly, estimates of the incidence of untoward sexual experience and performance cited in product labeling are likely to underestimate their actual incidence. Table 3 shows that the incidence rates of sexual side effects in patients with major depressive disorder are comparable to the placebo rates in placebo-controlled trials.

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To define the risk of hypertensive crises with use of Emsam, several Phase I tyramine challenge studies were conducted both with and without food. Preventing the signs of aging. Do not stop using this medicine without asking your doctor. If you have not used your medicine for several days in a row, do not start using it again without talking to your doctor first. Use only one patch at a time. While you are wearing the patch, do not expose it to sunlight or other sources of heat such as a heating pad, electric blanket, hot tub, or sauna. If your patch falls off or if you miss a dose of Emsam system, apply a new patch to a new site and resume your previous schedule.

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Epinephrine is a chemical that narrows blood vessels and opens airways in the lungs. These effects can reverse severe low blood pressure, wheezing, severe skin itching, hives, and other symptoms of an allergic reaction. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. HCl in 12 healthy male and female volunteers.

Feighner JP, Boyer WF, Tyler DL, Neborsky RJ. Adverse consequences of fluoxetine-MAOI combination therapy. You may have thoughts about suicide when you first start using an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment. Some stimulants have caused sudden death in children and adolescents with serious heart problems or congenital heart defects. Tell your doctor if you have a congenital heart defect. There are no specific antidotes for Emsam.

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